We Can Finally Stop Worrying About SGLT2 Inhibitors and Acute Kidney Injury

Can we prevent acute kidney injury?

OBJECTIVE To review the literature on prevention of acute kidney injury (AKI). DATA SOURCE MEDLINE- and PubMed-based review of literature published from 1965 to 2007. CONCLUSIONS AKI is very common among critically ill patients. Even mild forms of AKI have significant attributable mortality. Hence, it is imperative that every effort to prevent AKI be made in clinical practice. However, ther...

SGLT2 Inhibitors and the Diabetic Kidney.

Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. Blood glucose and blood pressure control reduce the risk of developing this complication; however, once DN is established, it is only possible to slow progression. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, the most recent glucose-lowering oral agents, may have the potential to exert nephroprotectio...

Ontotherapy, or how to stop worrying about what there is

The paper argues that Guarino is right that ontologies are different from thesauri and similar objects, but not in the ways he believes: they are distinguished from essentially linguistic objects like thesauri and hierarchies of conceptual relations because they unpack, ultimately, in terms of sets of objects and individuals. However this is a lonely status, and without much application outside...

Doing the right thing: stop worrying about cholesterol.

Stop worrying; start growing

Ever since the Asilomar Conference on ‘Recombinant DNA’ in February 1975, regulatory policies relating to recombinant DNA technology have focused on the idea that this technology implies threats to human health and the environment [1]. As a consequence, the explicit goal of these policies is to protect society and nature from an assumed hazard, or, if protection is not possible, at least to del...